[IMA-GregT]

👍 Thanks very much dickatlee. Bound to kick off a brilliant D..iscussion.

[Cindi Anderson]

There should be more discussion also about how getting vit D from sun is better than supplementation, and that sun has many other benefits that are important for health.

[Christel Martin]

I’m not surprised. EMF from wireless devices interferes with Calcium Channel Blockers (see Dr. Martin Pall’s work), causes all kinds of brain cancers (esp. glioblastoma) and cancers where you carry your phone, as well as osteoporosis if you carry it in your hip pocket and interferes with sugar metabolism, i.e. diabetes type 3, aka Alzheimers. See the Environmental Health Trust, Dr. Magda Havas, Dr. Olle Johannsen, Citizens for Safe Technology, Frank Clegg, Safe Living Technologies, Dr. Sam Milham about dirty electricity. . .have fun, there’s lots to learn. None of it is good for health of ANY living creature.

[robin-whittle]

Ultraviolet-B light, which is naturally available only from high elevation sunlight, without glass, clothing or sunscreen intervening, breaks a bond in one of the carbon rings of 7-dehydrocholesterol, creating a new molecule which transforms itself into vitamin D3 cholecalciferol. This is the natural source of almost all the vitamin D3 humans have relied upon until recently, since there is at best very small amounts of vitamin D3 in only a handful of foods.

The trouble is that this same, ca. 293 nanometre, high energy per excited electron, UV-B also breaks bonds in DNA, damaging the DNA and other molecules and so increasing the risk of skin cancer. Fortunately, supplemental vitamin D3 is now available. For 70 kg (154 lb) body weight without obesity, Prof. Wimalawansa recommends https://imahealth.org/understanding-the-health-benefits-of-vitamin-d/ supplementing 4900 to 6300 IUs of vitamin D3 a day, on average. This sounds like a lot, but the rather grand “5000 International Units” is 125 millionths of a gram. This amounts to a gram every 22 years – and pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. (Credit cards weigh just over 5 grams.)

There is very little vitamin D in food, including foods which are fortified with vitamin D3 or the less effective vitamin D2. Vitamin D3 can be produced in substantial quantities from UV-B exposure of ideally white skin, but this is not naturally available all year round to most people who live far from the equator, since it requires sunshine in the middle of summer days – not early in the morning or late in the afternoon. In a given day, there is no extra benefit of being exposed to about 1/3 of the amount of UV-B which is required to redden the skin.* However, all such exposure exposes the DNA in the skin to damage. There are health benefits from exposure to sunshine, but to rely entirely on UV-B skin exposure to attain the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D the immune system needs to function properly would also greatly raise the risk of skin cancer.

Consequently, most people cannot be fully healthy without proper vitamin D3 supplementation in quantities, which while small, are 5 to 10 or more (for those suffering from obesity) the minuscule 1000 IU (25 micrograms) per day quantities many doctors recommend.

If we had no supplemental vitamin D3, health would be optimized by some level of UV-B skin exposure which trades off the skin cancer risk against the essential benefits of improving immune system function by raising 25-hydroxyvitamin D levels. However, since supplemental vitamin D3 (produced by UV-B irradiation of 7-dehydrocholesterol made from wool fat https://sci-hub.se/10.1016/B978-0-12-381978-9.10006-X) is so inexpensive and readily available, the best approach is to supplement properly and avoid excessive UV-B exposure.

* Determining an Effective UV Radiation Exposure Time for Vitamin D Synthesis in the Skin Without Risk to Health: Simplified Estimations from UV Observations, Masaatsu Miyauchi and Hideaki Nakajima, Photochemistry and Photobiology 2016-10-18 https://onlinelibrary.wiley.com/doi/10.1111/php.12651.

imahealth.org

Just a moment...

Just a moment...

[IMA-GregT]

👍

[IMA-GregT]

👍 Just to mention, qofmiwok, there is a bunch on our website on getting Vit D from the sun – https://imahealth.org/?s=vitamin+d&id=6377.

imahealth.org

Just a moment...

Just a moment...

[robin-whittle]

The 2013 article “Electrosmog and autoimmune disease” by Trevor Marshall and a colleague is highly speculative and is nowhere near the level of observational, experimental and mechanistic theory work which would be required to argue that actual levels of microwave signal, in the GHz range, inside the human body, have a significant effect on the “Vitamin D Receptor”. This molecule is best thought of as the calcitriol (1,25-dihydroxyvitamin D) receptor, since this is the compound which binds most strongly to it. It binds much less strongly to 25-hydroxyvitamin D (calcifediol AKA calcidiol) and to vitamin D3 (cholecalciferol).

That article concerns a computer simulation of the VDR molecule in which the authors report slight changes in behavior which they think might be important, when the molecule is subject to particular microwave frequencies.

Conductive materials such as flesh tend to shield and absorb microwaves, so there would be less signal strength inside the body, beyond some depth, than at the surface. Nonetheless, biology is very subtle and the influence of electromagnetic waves on delicate chemical processes should not be dismissed without careful consideration.

In a comment in Dr Kory’s Substack https://pierrekorymedicalmusings.com/p/my-expert-review-of-the-medical-records/comment/108458774 suggesting that the IMA develop a Vitamin D Protocol, applicable to all people, of all ages and body weights, received 17 Likes. The centerpiece of this would be Prof. Sunil Wimalawansa’s recommendations for how much vitamin D3 to supplement, on average, per day, according to body weight and obesity status. See his recent IMA article which includes these recommendations: https://imahealth.org/understanding-the-health-benefits-of-vitamin-d/. These are intended to attain 50 ng/mL or more circulating 25-hydroxyvitamin D (as measured in “vitamin D” blood tests) – which is the minimum level the immune system needs to function properly.

Many types of immune cell require a good supply of 25-hydroxyvitamin D (made primarily in the liver by hydroxylating vitamin D3 cholecalciferol on the 25th carbon) in order to run their intracrine (inside an individual cell) signaling systems. This is also referred to somewhat incorrectly as “autocrine” signaling. This, and a related paracrine signaling system (between nearby cells, often of different types) are crucial to the ability of many types of immune cell to respond to their changing circumstances. Since very few doctors and immunologists have heard or, or understand these systems, and since there is no peer-reviewed tutorial on them, I wrote a web page tutorial in 2020: https://vitamindstopscovid.info/02-intracrine/.

A somewhat simplified explanation is part of https://vitamindstopscovid.info/00-evi/, which cites a great deal of research on the vitamin D compounds and the immune system. This page also mentions research on how low levels of 25-hydroxyvitamin D increase the risk autism, ADHD, preeclampsia, low birthweight, pre-term birth and mental retardation: https://vitamindstopscovid.info/00-evi/#3.2. I have not ye added a link to “Neonatal vitamin D deficiency was associated with an increased risk for schizophrenia in later life.” https:/ http://www.nature.com/articles/ s41598-018-35418-z. Likewise neurodegeneration – Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy etc.: https://vitamindstopscovid.info/00-evi/#3.3.

These intracrine and paracrine signaling are unrelated to hormonal (endocrine) signaling. The hormonal action of circulating calcitriol, maintained at a very low level ca. 0.05 to 0.1 ng/mL by the kidneys, on distant cell types which are involved in calcium-phosphate-bone metabolism is well understood by all doctors. 25-hydroxyvitamin D to calcitriol intracrine and paracrine signaling is unrelated to hormonal signaling. In these, the intracellularly produced calcitriol functions as an intracrine agent and paracrine agent, respectively, binding to the VDR molecule which then binds to the retinol-X molecule in the nucleus and alters gene expression – and so protein manufacture and cell behavior – in cell-type-specific ways. Neither vitamin D3 nor 25-hydroxyvitamin D act as hormones. They are not signaling molecules.

pierrekorymedicalmusings.com

Robin Whittle on Pierre Kory’s Medical Musings

Thanks Dr Kory for all your great work and for supporting what I wrote. I believe the IMA needs a Vitamin D Protocol, for all ages, body weights and degrees of obesity, based on Prof. Wimalawansa's recommendations for how much … Continue reading

[IMA-GregT]

Thanks very much Robin-Whittle 👍 Brilliant detail.