There are emerging evidence and studies that using methylene blue and near infrared light in combination can treat skin cancer. I have both of these at home and if I were to be diagnosed with skin cancer it would be my first stop, mostly because it is so easy to do. I’ve already fixed conditions that appeared on my skin (I had posted photos previously of before and after) and without any diagnosis of what it was.
Key Emerging Evidence
– Systematic Review (2023, Frontiers in Pharmacology): Reviewed 10 preclinical studies and found that MB-PDT reduced tumor size in models of melanoma, colorectal carcinoma, and squamous cell carcinoma. Effectiveness increased when MB was delivered via nanoparticles or liposomes, which improved penetration and stability.
– Nanotechnology Approaches (2023, Pharmaceutics): Encapsulating MB in nanoparticles enhanced skin penetration and phototoxicity against squamous cell carcinoma cells. ROS generation and cell death were significantly higher when MB was combined with red light.
– Mechanistic Insights (2025 review): MB-PDT in melanoma cells triggers mitochondrial dysfunction, caspase activation, and apoptosis. In ovarian and glioblastoma models, MB also reversed the Warburg effect (shifting metabolism back toward oxidative phosphorylation), which may slow cancer growth.
– Clinical Context (WebMD, NCI): Photodynamic therapy is already FDA-approved for actinic keratosis, basal cell carcinoma, and Bowen’s disease using other photosensitizers. MB is being studied as a potentially safer, cheaper, and more effective alternative, but large-scale clinical trials are still lacking