Pulmonary Fibrosis and YAP/TAZ proteins

  • Pulmonary Fibrosis and YAP/TAZ proteins

    Posted by lisav on March 9, 2026 at 9:45 pm EDT

    A friend has been diagnosed w/Pulmonary Fibrosis. I did a quick internet search about it. Came across this article:
    Pulmonary fibrosis: Study targets proteins to reverse lung scarring

    https://www.sciencedaily.com/releases/2025/02/250219225212.htm

    I then did a search on IMA Health for YAP and TAZ. The results mention these in cancer info. Does anyone know of other info re these proteins directly related to PF?

    Thanks in advance for any help

    lisav replied 3 days, 13 hours ago 5 Members · 7 Replies
  • 7 Replies
  • Hassan Shire

    Member
    March 9, 2026 at 10:25 pm EDT

    I dont know much about look for high vit c dose

  • James Kringlee

    Member
    March 10, 2026 at 12:47 am EDT

    Dr Darrel DeMello used the Corticosteroid dexamethasone for a shorter time and colchicine tapering over up to 6 months to reverse covid induced Pulmonary Fibrosis. As with most all diseases the earlier the treatment is initiated the better.

    • lisav

      Member
      March 10, 2026 at 4:14 pm EDT

      Thank you. I’ll check it out.

  • judy-j

    Member
    March 10, 2026 at 1:51 am EDT

    A Midwestern Doctor on substack has articles on DMSO and people get good results with using DMSO to reverse pulmonary fibrosis. Check out that info.

    • lisav

      Member
      March 10, 2026 at 4:16 pm EDT

      Thank you! AMD is one of my favorite SS writers. I’ll see if I can find the articles addressing this.

  • IMA-HelenT

    Organizer
    March 10, 2026 at 10:41 am EDT

    Did a quick AI search … for papers specifically for PF

    Key Papers Specifically on YAP/TAZ and Pulmonary Fibrosis

    These are some of the most cited:

    1. Liu et al., 2015 – American Journal of Physiology Lung
      YAP/TAZ activation in lung fibroblasts promotes pulmonary fibrosis.

    2. Piersma et al., 2015 – American Journal of Physiology
      YAP1 is a mechanosensitive driver of myofibroblast differentiation.

    3. Liu F. et al., 2017 – Nature Communications
      Mechanosignaling through YAP/TAZ drives lung fibrosis.

    4. Noguchi et al., 2020 – Journal of Clinical Investigation
      YAP/TAZ regulate epithelial regeneration and fibrosis.

    5. 2023–2024 reviews
      Several reviews now describe YAP/TAZ as central regulators of fibrotic lung disease.

    6. Worth exploring AI around research looking at new Therapeutic compounds being explored to modulate the Hippo/YAP pathway

    • lisav

      Member
      March 10, 2026 at 4:17 pm EDT

      Thank you, Helen, I’ll definitely read these!

Log in to reply.