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On protocols with Parkinson’s, Lewy Body, ALS?
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On protocols with Parkinson’s, Lewy Body, ALS?
I’m looking for help with several neurological issues: Lewy Body, PD, and another yet-unknown neurological issue with a friend – ALS-like symptoms, but it’s been ruled out.
I know that Dr Makis has published some case notes on patients self-reporting dramatic improvements to PD symptoms while on IVM & FBZ/MBZ.
Are there any particular IMA groups known, or data known WRT repurposed drugs, nutraceuticals, etc, on these neuro issues?
The typical PD treatments are loosing ground in this particular case, and the patient is open to any options and recommendations.
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6 Replies
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Please see the research cited and discussed at: https://vitamindstopscovid.info/00-evi/. Low 25-hydroxyvitamin D is a huge risk factor for neurodegeneration: https://vitamindstopscovid.info/00-evi/#3.3 and (in pregnancy and early childhood) preeclampsia, pre-term birth, mental retardation, ADHD and autism: https://vitamindstopscovid.info/00-evi/#3.2.
A good friend of mine died recently, in his mid-60s, from multiple system atrophy. I had not heard of this when I first learned of his severely disabling illness three years ago.
The etiology of multiple system atrophy is essentially the same as that of Parkinson’s disease and dementia with Lewy bodies. All three involve misfolding (prion disease) of the same α-synuclein protein, which exists naturally in the brain. Ayers et al. 2022 https://www.pnas.org/doi/abs/10.1073/pnas.2113489119 established that the difference between these three diseases (which are really three somewhat different sets of symptoms) is that the self-catalysing (prion) misfolding pattern is different for each of these three, though the researchers could not discover exactly what the misfolding patterns were.
When I first searched Google Scholar for “multiple system atrophy” and “vitamin D” it took me two or so minutes to find Ogura et al. 2021 https://www.sciencedirect.com/science/article/pii/S2405650221000617 who report that healthy controls averaged 26.8 ng/mL circulating 25-hydroxyvitamin D (half of what the immune system needs to function properly) while Parkinson’s disease patients averaged 13.4 ng/mL and multiple system atrophy patients 10.5 ng/mL. (Both p = 0.0001.)
Evatt et al. 2011: https://sci-hub.se/10.1001/archneurol.2011.30 found that the low 25-hydroxyvitamin D levels in PD etc. patients is not, or is perhaps only very slightly, due to reverse causation (the disease lowering the level). So the causality flows primarily or solely from low 25-hydroxyvitamin D levels to neurodegeneration.
Alzheimer’s disease and numerous other kinds of neurodegeneration follow the same pattern, as you can read from the research cited and discussed at: https://vitamindstopscovid.info/00-evi/#3.3.
To see how much vitamin D3 to supplement, on average, per day, to ensure at least 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D all year round, according to body weight and obesity status, please see the recommendations of New Jersey Professor of Medicine Sunil Wimalawansa at: https://vitamindstopscovid.info/00-evi/#00-how-much.
Low dose, 5mg/day, non-prescription lithium (orotate) supplementation may reduce dementia risk: https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-024-00348-5, https://www.nature.com/articles/s41586-025-09335-x, https://chandramd.com/low-dose-lithium-supplements/, pubmed.ncbi.nlm.nih.gov/35236261/, https://www.nytimes.com/2014/09/14/opinion/sunday/should-we-all-take-a-bit-of-lithium.html.
Vitamin K2 supplementation may reduce the risk of neurodegeneration: https://scholar.google.com.au/scholar?hl=en&as_sdt=0%2C5&q=%22vitamin+K2%22+neurodegeneration&btnG=, https://link.springer.com/article/10.1007/s11033-022-07925-w, https://link.springer.com/article/10.1007/s11481-024-10156-4, https://www.researchgate.net/publication/378839625_The_Role_of_Vitamin_K_in_the_Development_of_Neurodegenerative_Diseases, Vitamin K2 AD prevention and treatment, Popescu 2021 https://www.mdpi.com/2072-6643/13/7/2206.
The above items mainly concern prevention, in the decades before the disease would become apparent if the neurodegenerative processes had continued. However, they are surely all relevant for treatment.
In 2022 I wrote some notes on potential treatments for neurodgenerative diseases such as Parkinsons disease, Dementia with Lewy bodies, Alzheimer’s disease, multiple system atrophy etc. This is not a public page so please don’t link to it from any public page, where search engine spiders might find it. https://5nn.info/99-PD-DLB-MSA/ This forum is password protected, so search engines cannot index what we write here.
This page links to indications that the high vitamin D3 supplementation Coimbra Protocol may help reverse Parkinsons disease, and so perhaps some or all of the other neurodegenerative diseases. For more on this protocol, and how it is effective against much the same broad set of autoimmune inflammatory disorders as helminthic therapy, please see: https://vitamindstopscovid.info/06-adv/.
Theres a video at: https://www.facebook.com/coimbraprotocol.vitamind/videos/parkinsons-disease/199159654612033/ which depicts a man playing the piano, after greatly improving his Parkinson’s disease condition thanks to the Coimbra Protocol. I have no way of checking the veracity of this, but I guess it is true since I can’t imagine why someone would create such a video and page except for genuine reasons.
There is peer-reviewed research on using fenbendazole and perhaps ivermectin to treat cancer: https://scholar.google.com.au/scholar?hl=en&as_sdt=0%2C5&q=fenbendazole+cancer&btnG=. Dr William Makis has a busy Substack, which is only accessible to paid subscribers, which focuses on this: https://makisw.substack.com. I have not tried to read and evaluate all this work. This search term points to articles he has written which are apparently testimonies from people, or their relatives, who have found that ivermectin and/or fenbendazole helps with dementia: https://www.google.com/search?q=site%3Amakisw.substack.com++dementia&lr=&sca_esv=b27cdfc5effed82d&as_qdr=all&ei=QxwgaYL3H-aQur8P2LjI4A4&ved=0ahUKEwjCpJW644KRAxVmiO4BHVgcEuwQ4dUDCBE&uact=5&oq=site%3Amakisw.substack.com++dementia&gs_lp=Egxnd3Mtd2l6LXNlcnAiInNpdGU6bWFraXN3LnN1YnN0YWNrLmNvbSAgZGVtZW50aWFI6yNQxwNYyx5wAngAkAEAmAH2BaAByhiqAQkwLjUuMy42LTK4AQPIAQD4AQGYAgCgAgCYAwCIBgGSBwCgB8IDsgcAuAcAwgcAyAcA&sclient=gws-wiz-serp
None of the above is medical advice. I am an electronic technician and computer programmer.
vitamindstopscovid.info
Vitamin D and the Immune System - how much vitamin D3 to take, by body weight and obesity status
Vitamin D and the Immune System - how much vitamin D3 to take, by body weight and obesity status
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I don’t have any information on IVM & FBZ/MBZ but the information below may be of interest:
Impact of a keto diet on symptoms of Parkinson’s disease, biomarkers, depression, anxiety and quality of life: a longitudinal study
https://keto-mojo.com/research/keto-parkinsons-quality-of-life/?
“For 24 weeks, participants followed a ketogenic diet providing approximately 1750 calories and 152 grams of fat, 75 grams of protein, and less than 20 grams of net carbohydrates daily.
Participants reported enhanced cognitive function, mood, motor and nonmotor symptoms; reduced pain and anxiety; and overall improvements in quality of life. All seven expressed a commitment to maintaining the ketogenic diet for ongoing health benefits.”
So You Have Parkinson’s Disease—Now What?: An Eight-Year Research Review into Metabolic Health and Hope
https://keto-mojo.com/blog/so-you-have-parkinsons-disease
Are Ketones the cure big pharma doesn’t want you to know about? With Dr. Stephen Cunnane
Parkinson’s mentioned around 55 min mark.
Bedridden No More: Carnivore Journey to Overcome Parkinson’s, RA, Stroke & Thrive!
Episode 218: “I Ate ONLY ONE Food And My Parkinson’s REVERSED!” | Mimi Morgan
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Books:
Natural Therapies For Parkinson’s Disease by Dr Laurie Mischley
Ending Parkinson’s Disease: A Prescription for Action by neurologist Dr. Ray Dorsey.
The Radical Message Behind the New Book, The Parkinson’s Plan: “We Have a Chance to Get Rid of This Disease”
https://www.themahareport.com/p/the-radical-message-behind-new-book?
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Benefits of Vitamins in the Treatment of Parkinson’s Disease
https://onlinelibrary.wiley.com/doi/10.1155/2019/9426867
http://www.doctoryourself.com/parkinson.html
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Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease
https://www.sciencedirect.com/science/article/abs/pii/S1568163718300680
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RHR: A Functional Medicine Approach to Parkinson’s Disease
https://chriskresser.com/a-functional-medicine-approach-to-parkinsons-disease/
New Research and Treatments for Parkinson’s Disease
https://chriskresser.com/new-research-and-treatments-for-parkinsons-disease/
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Parkinson’s hope as scientists find a probiotic can stop and even REVERSE the build-up of toxic clumps in brain that cause tremors
“Parkinson’s hope as scientists find a probiotic can stop and even REVERSE the build-up of toxic clumps in brain that cause tremors
Probiotic bacillus subtilis prevented the formation of toxic clumps of protein
Alpha-synuclein blocks production of dopamine, which controls movement
Campaigners said findings were ‘exciting’ as they highlight link to the gut”
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Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson’s disease
https://pubmed.ncbi.nlm.nih.gov/23636255/
Dr. Giselle Petzinger, an associate professor of Neurology at the University of Southern California studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.
https://www.foundmyfitness.com/episodes/giselle-petzinger
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Light, Obesity, and COVID-19 – The Melatonin Connection
https://www.evolutamente.it/en/light-obesity-and-covid-19-the-melatonin-connection/
“interestingly, extensive research on melatonin indicates that this chemical of darkness plays an exceedingly protective role in neurodegenerative diseases, especially in Parkinson’s disease, and Alzheimer’s disease [49-53].”
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Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implications
https://pmc.ncbi.nlm.nih.gov/articles/PMC7164543/
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Nicotine does WHAT in Parkinson’s?!?!
https://www.youtube.com/shorts/bkqfMTHDtXE
Look up Dr Bryan Ardis for more on Nicotine and nicotine patches.
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https://www.facebook.com/share/p/1CzrxcY83B/?
In a stunning discovery, researchers at the University of Sydney have successfully reversed Parkinson’s-like symptoms in mice by restoring balance to a single brain protein SOD1. Normally protective, this protein goes rogue in Parkinson’s disease, clumping and damaging neurons.
The scientists used a targeted copper supplement to stabilize SOD1, and the results were remarkable: the treated mice regained normal movement, while untreated ones continued to decline. The findings suggest that correcting this protein’s malfunction could halt or even reverse the disease’s progression.
While human trials are next, the study opens an exciting new direction for treating Parkinson’s not by masking symptoms, but by repairing what’s broken at the molecular level.
Source: University of Sydney, Acta Neuropathologica Communications (2025) DOI: 10.1186/s40478-025-02048-2
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Addressing the Neuroprotective Actions of Coffee in Parkinson’s Disease: An Emerging Nutrigenomic Analysis
https://pubmed.ncbi.nlm.nih.gov/36009304/
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You could find a Functional Medicine Practitioner to work with (Most do online consultations):
https://www.ifm.org/find-a-practitioner/
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Thanks @pg really helpful
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wow – thanks for that data dump! super helpful!
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Please see the research cited and discussed at: https://vitamindstopscovid.info/00-evi/. Low 25-hydroxyvitamin D is a huge risk factor for neurodegeneration: https://vitamindstopscovid.info/00-evi/#3.3 and (in pregnancy and early childhood) preeclampsia, pre-term birth, mental retardation, ADHD and autism: https://vitamindstopscovid.info/00-evi/#3.2.
A good friend of mine died recently, in his mid-60s, from multiple system atrophy. I had not heard of this when I first learned of his severely disabling illness three years ago.
The etiology of multiple system atrophy is essentially the same as that of Parkinson’s disease and dementia with Lewy bodies. All three involve misfolding (prion disease) of the same α-synuclein protein, which exists naturally in the brain. Ayers et al. 2022 https://www.pnas.org/doi/abs/10.1073/pnas.2113489119 established that the difference between these three diseases (which are really three somewhat different sets of symptoms) is that the self-catalysing (prion) misfolding pattern is different for each of these three, though the researchers could not discover exactly what the misfolding patterns were.
When I first searched Google Scholar for “multiple system atrophy” and “vitamin D” it took me two or so minutes to find Ogura et al. 2021 https://www.sciencedirect.com/science/article/pii/S2405650221000617 who report that healthy controls averaged 26.8 ng/mL circulating 25-hydroxyvitamin D (half of what the immune system needs to function properly) while Parkinson’s disease patients averaged 13.4 ng/mL and multiple system atrophy patients 10.5 ng/mL. (Both p = 0.0001.)
Evatt et al. 2011: https://sci-hub.se/10.1001/archneurol.2011.30 found that the low 25-hydroxyvitamin D levels in PD etc. patients is not, or is perhaps only very slightly, due to reverse causation (the disease lowering the level). So the causality flows primarily or solely from low 25-hydroxyvitamin D levels to neurodegeneration.
Alzheimer’s disease and numerous other kinds of neurodegeneration follow the same pattern, as you can read from the research cited and discussed at: https://vitamindstopscovid.info/00-evi/#3.3.
To see how much vitamin D3 to supplement, on average, per day, to ensure at least 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D all year round, according to body weight and obesity status, please see the recommendations of New Jersey Professor of Medicine Sunil Wimalawansa at: https://vitamindstopscovid.info/00-evi/#00-how-much.
Low dose, 5mg/day, non-prescription lithium (orotate) supplementation may reduce dementia risk: https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-024-00348-5, https://www.nature.com/articles/s41586-025-09335-x, https://chandramd.com/low-dose-lithium-supplements/, pubmed.ncbi.nlm.nih.gov/35236261/, https://www.nytimes.com/2014/09/14/opinion/sunday/should-we-all-take-a-bit-of-lithium.html.
Vitamin K2 supplementation may reduce the risk of neurodegeneration: https://scholar.google.com.au/scholar?hl=en&as_sdt=0%2C5&q=%22vitamin+K2%22+neurodegeneration&btnG=, https://link.springer.com/article/10.1007/s11033-022-07925-w, https://link.springer.com/article/10.1007/s11481-024-10156-4, https://www.researchgate.net/publication/378839625_The_Role_of_Vitamin_K_in_the_Development_of_Neurodegenerative_Diseases, Vitamin K2 AD prevention and treatment, Popescu 2021 https://www.mdpi.com/2072-6643/13/7/2206.
The above items mainly concern prevention, in the decades before the disease would become apparent if the neurodegenerative processes had continued. However, they are surely all relevant for treatment.
In 2022 I wrote some notes on potential treatments for neurodgenerative diseases such as Parkinsons disease, Dementia with Lewy bodies, Alzheimer’s disease, multiple system atrophy etc. This is not a public page so please don’t link to it from any public page, where search engine spiders might find it. https://5nn.info/99-PD-DLB-MSA/ This forum is password protected, so search engines cannot index what we write here.
This page links to indications that the high vitamin D3 supplementation Coimbra Protocol may help reverse Parkinsons disease, and so perhaps some or all of the other neurodegenerative diseases. For more on this protocol, and how it is effective against much the same broad set of autoimmune inflammatory disorders as helminthic therapy, please see: https://vitamindstopscovid.info/06-adv/.
Theres a video at: https://www.facebook.com/coimbraprotocol.vitamind/videos/parkinsons-disease/199159654612033/ which depicts a man playing the piano, after greatly improving his Parkinson’s disease condition thanks to the Coimbra Protocol. I have no way of checking the veracity of this, but I guess it is true since I can’t imagine why someone would create such a video and page except for genuine reasons.
There is peer-reviewed research on using fenbendazole and perhaps ivermectin to treat cancer: https://scholar.google.com.au/scholar?hl=en&as_sdt=0%2C5&q=fenbendazole+cancer&btnG=. Dr William Makis has a busy Substack, which is only accessible to paid subscribers, which focuses on this: https://makisw.substack.com. I have not tried to read and evaluate all this work. This search term points to articles he has written which are apparently testimonies from people, or their relatives, who have found that ivermectin and/or fenbendazole helps with dementia: https://www.google.com/search?q=site%3Amakisw.substack.com++dementia&lr=&sca_esv=b27cdfc5effed82d&as_qdr=all&ei=QxwgaYL3H-aQur8P2LjI4A4&ved=0ahUKEwjCpJW644KRAxVmiO4BHVgcEuwQ4dUDCBE&uact=5&oq=site%3Amakisw.substack.com++dementia&gs_lp=Egxnd3Mtd2l6LXNlcnAiInNpdGU6bWFraXN3LnN1YnN0YWNrLmNvbSAgZGVtZW50aWFI6yNQxwNYyx5wAngAkAEAmAH2BaAByhiqAQkwLjUuMy42LTK4AQPIAQD4AQGYAgCgAgCYAwCIBgGSBwCgB8IDsgcAuAcAwgcAyAcA&sclient=gws-wiz-serp
None of the above is medical advice. I am an electronic technician and computer programmer.
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Internist Lawrence Broxmeyer documents voluminous references to older medical literature showing extreme similarity between Parkinson’s and malarial “brain fever”. He suggests that Parkinson’s patients therefore be treated for malaria.
His books are sold on amazon.
Also, the substantia nigra is interestingly an iodine-rich region of the brain.
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