Ways someone can “build up an intolerance” to ivermectin
1. Sensitivity from repeated use.
Some people notice that after taking ivermectin many times, they start having:
- headaches
- dizziness
- nausea
- fatigue
- skin itching
This isn’t a traditional allergy; it’s more like the body becoming less tolerant of the medication’s effects.
2. Gut/liver processing changes
Ivermectin is processed largely through the liver. Repeated or high-dose use may:
- slow processing
- increase sensitivity to side effects
- cause “intolerance-like” symptoms
Especially if someone has:
- fatty liver
- sluggish detox pathways
- MTHFR variants
- chronic inflammation
- mold toxicity
- multiple medications (competition for liver enzymes)
3. Interaction with the nervous system
A very small number of people may accumulate ivermectin in the nervous system if:
- the blood-brain barrier is compromised
- there is inflammation
- they take certain medications that inhibit P-glycoprotein (like some antifungals or calcium channel blockers)
This could feel like new or worsening intolerance:
- dizziness
- foggy head
- tingling
- anxiety or wired feelings
4. Misinterpreting “die-off” (Herxheimer reactions)
When parasites, mold, or certain microbes are killed, the immune system reacts. This can cause:
- flu-ish feeling
- body aches
- fatigue
- headache
- chills
If this happens repeatedly, people think they’re becoming “intolerant,” but it’s usually immune-related, not drug intolerance.
5. Actual allergy (rare)
True allergy symptoms:
- rash or hives
- swelling of lips/tongue
- wheezing
- throat closing sensation
This almost never develops gradually — it’s usually evident from early doses.❗ When it looks like intolerance but isn’t
People with any of these conditions frequently react more strongly over time:
- mold/mycotoxin illness
- Lyme / Bartonella
- mast cell activation syndrome (MCAS)
- POTS
- chronic inflammation
- liver congestion or sluggish detox
In these cases, ivermectin isn’t the problem — the terrain is.