[IMA-GregT]

Great question, which meant a bit of research required (just to understand the question as I’m not medically trained.)

From AI.

Dientamoeba fragilis

General Characteristics

• Dientamoeba fragilis is a protozoan parasite that mainly inhabits the human colon. It belongs to the order Tritrichomonadida, although it has lost the flagella typical of this group.

• Its main form is the trophozoite, which is amoeboid in shape, with 1 or 2 nuclei, and measures 7–12 μm.

• It lacks mitochondria, has a Golgi apparatus called a parabasal body, and feeds by phagocytosis and pinocytosis.

• Reproduction is asexual, by longitudinal binary fission.

• Traditionally, it was thought not to form cysts, but recent research suggests cysts may be present, sometimes found in the eggs of helminths like Ascaris lumbricoides.

Epidemiology and Transmission

• It is cosmopolitan and monoxenous (one host).

• Risk factors include contact with children, rural living, and coinfection with Enterobius vermicularis.

• The exact mode of transmission is still debated, but fecal-oral transmission and via helminth eggs have been suggested.

Clinical Features

• It can cause gastrointestinal symptoms such as abdominal pain, diarrhea, and eosinophilia, although many carriers are asymptomatic.

• It has been linked to irritable bowel syndrome (IBS) and, in some cases, to extraintestinal symptoms like urticaria.

• Its clinical relevance is controversial, as it is also found in healthy individuals.

Diagnosis and Treatment

• Diagnosis requires specific techniques such as staining, culture, and now molecular methods (PCR), which increase sensitivity.

• The treatment of choice is paromomycin, which has better cure rates than metronidazole.

Blastocystis hominis (Blastocystis sp.)

General Characteristics

• Blastocystis hominis is a pleomorphic, strictly anaerobic unicellular protozoan with a high worldwide prevalence.

• It has several morphological forms: vacuolar, avacuolar, granular, cystic, and amoeboid.

• It infects humans and a wide variety of animals (birds, rodents, reptiles, fish, etc.).

Epidemiology and Transmission

• Transmitted by ingestion of cysts present in water or food contaminated with fecal matter.

• It is the most common parasite in human stool samples, with prevalence varying by region and hygiene conditions.

Clinical Features

• Its pathogenic role is controversial: many carriers are asymptomatic, but in some cases, it can cause gastrointestinal symptoms such as diarrhea, abdominal pain, nausea, vomiting, gas, fatigue, and weight loss.

• It has been linked to irritable bowel syndrome and, occasionally, to skin manifestations.

• The variability in pathogenicity may be explained by different genetic subtypes and host factors.

Diagnosis and Treatment

• Diagnosis is by microscopic stool examination, but sensitivity increases with serial samples and molecular techniques (PCR), which also allow subtype identification.

• The most commonly used treatment is metronidazole, though efficacy may vary; tinidazole and nitazoxanide are also used.

Comparison: Dientamoeba fragilis vs Blastocystis hominis

*IBS: Irritable Bowel Syndrome

Current Considerations

• Both parasites are common in humans, and their role as pathogens is still debated since they can be found in both symptomatic and asymptomatic individuals.

• Improved diagnostic techniques, especially molecular ones, are helping to better understand their epidemiology and possible clinical impact.

• In patients with persistent gastrointestinal symptoms, especially with irritable bowel syndrome, it is recommended to test for these parasites and consider treatment if detected.

[IMA-GregT]

And here’s the AI response to – Can ivermectin eradicate these two parasites? (Please always take AI’s responses with an understanding that they will have been given algorithmic insruction to answer a certain way.)

My expectation is that those reading who have actual knowledge and experience will be bale to answer more profoundly.

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Based on current evidence from the provided sources, here’s the breakdown of ivermectin’s efficacy against Dientamoeba fragilis and Blastocystis hominis:

Ivermectin for Dientamoeba fragilis

• No evidence of effectiveness:
  Ivermectin is not mentioned in any treatment guidelines or studies for D. fragilis infections135.
  The CDC and recent Finnish analyses recommend paromomycin (first-line) or metronidazole as primary treatments, with doxycycline and secnidazole as alternatives35.
  Benzimidazoles (e.g., albendazole) are explicitly stated to lack efficacy5, and no data support ivermectin for this parasite.

Ivermectin for Blastocystis hominis

• Promising in vitro results:
  Ivermectin demonstrated high effectiveness against Blastocystis in laboratory studies, showing lethal effects at concentrations of 125 μg/ml246.

  • Subtypes ST1, ST3, ST4, and ST8 all responded to ivermectin in vitro26.

  • Compared to metronidazole (which showed poor efficacy), ivermectin was more potent26.

• Limited clinical data:
  While effective in vitro, ivermectin has not been widely tested in human trials for blastocystosis46.
  Current clinical guidelines still prioritize trimethoprim-sulfamethoxazole (TMP-SMX) or nitazoxanide due to better evidence246.

Key Takeaways

• For Blastocystis, ivermectin represents a potential future option but requires more clinical validation before replacing current first-line therapies26.

• Always consult a healthcare provider for personalized treatment plans.

Citations:

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC3862407/
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC4505275/
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC10542007/
4. https://en.wikipedia.org/wiki/Blastocystosis
5. https://www.cdc.gov/dientamoeba/hcp/clinical-care/index.html
6. https://journals.asm.org/doi/abs/10.1128/aac.04832-14
7. https://www.jstor.org/stable/40665151
8. https://emedicine.medscape.com/article/997239-medication
9. https://www.sciencedirect.com/science/article/pii/S0378608084800367
10. https://www.sciencedirect.com/science/article/pii/S2405673123000375
11. https://academic.oup.com/cid/article/54/1/105/369396
12. https://pmc.ncbi.nlm.nih.gov/articles/PMC3104918/
13. https://www.parasite-journal.org/articles/parasite/pdf/2024/01/parasite230178.pdf
14. https://www.rch.org.au/immigranthealth/clinical/Intestinal_Parasites/
15. https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.7446
16. https://www.rch.org.au/immigranthealth/clinical/Intestinal_parasites/
17. https://kahpf.squarespace.com/s/Parasitic-Worms.pdf

[lynn Russell]

I have not been diagnosed with parasites but have read they can cause dementia, MS, kidney disease and many other maladies. From Substack, I saw a natural remedy to “purge parasites “ using organic pumpkin seeds, organic papaya seeds, pomegranate arils, and oregano oil.

Recipe: chop together in food chopper:

2 cups pumpkin seeds, Half cup of papaya seeds, and Half cup pomegranate arils

Resulting in glumpy mix that can be refined further by hand, rubbing the big clumps together in your hands, messy but effective

Use “00” capsules, add 3 drops oregano oil before filling capsules with mix.

Take 2 capsules 3 times daily for 10 days, five days “off” without any, then repeat 10 days of 2 capsules 3 times daily. Parasite free.

At 77 years, I am just starting my second round and notice an increase in mental clarity and kidney function. I am very pleased.

[IMA-GregT]

❤ Thanks lynner4u. Sounds like a great option.

[Aznasimage]

Hominus can migrate to our eyes, so be cautious!

[IMA-GregT]

👍

[Christel Martin]

I follow [email protected] who is having amazing results with cancer therapy using anti-parasitic meds. You’ve got great info below and there are natural remedies, check black walnut, clove and . . . sorry can’t remember the other one. Good luck!

[IMA-GregT]

👍