In this fascinating study from UCSD, researchers demonstrate for the first time that time-restricted-feeding (TRF), or intermittent fasting, can synchronize neuronal tissue clocks. This results in the Alzheimer’s disease mice to have better sleep, improved sleep length, less irritability, better metabolic dynamics, reduced plaque load and improved plaque clearance, and improved abeta42/abeta40 ratio, with memory improvements almost equal to healthy mice. Let’s review.