Authors: Izquierdo JL, Soriano JB, Gonzalez Y, Lumbreras S PMID: 35084258 PMCID: PMC8795755 DOI: 10.1177/00368504221074574 Abstract Infection by SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) can be associated with serious and life-threatening conditions, including acute respiratory distress syndrome (ARDS). Severity and mortality have been related to a cytokine storm, an imbalance of oxidative stress, and a [...]

Authors: Patterson BK, Francisco EB, Yogendra R, Long E, Pise A, Hall E et al. PMID: 35082777 PMCID: PMC8784688 DOI: 10.3389/fimmu.2021.746021 AbstractThe recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to 30% of all infected [...]

Authors: Rondanelli M, Perna S, Gasparri C, Petrangolini G, Cavioni A, Peroni G. PMID: 35054459 PMCID: PMC8780248 DOI: 10.3390/life12010066 Abstract Quercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for the potential counterbalance of a COVID-19 infection. Given this background, the aim of the study was to evaluate the [...]

Authors: Santamarina MG, Beddings I, Martinez Lomakin F, Boisier Riscal D PMID: 34980198 PMCID: PMC8721481 DOI: 10.1186/s13054-021-03885-y Abstract Background: SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation-perfusion mismatch that can be characterized using subtraction computed tomography angiography (sCTA). This study aims to evaluate [...]

Authors: Pretorius E, Venter C, Laubshder G, Kotze M, Moremi K doi: https://doi.org/10.21203/rs.3.rs-1205453/v1 Abstract We recognise that fibrin(ogen) amyloid microclots and platelet hyperactivation, that we have previously observed in COVID-19 and Long COVID/Post-Acute Sequelae of COVID-19 (PASC) patients, might form a suitable set of foci for the clinical treatment of the symptoms of long COVID/PASC. [...]

Authors: Sabel BA, Zhou W, Huber F, Schmidt F, Sabel K PMID: 34924406 PMCID: PMC8764598 DOI: 10.3233/RNN-211249 Abstract Background: An effective treatment is needed for long-COVID patients which suffer from symptoms of vision and/or cognition impairment such as impaired attention, memory, language comprehension, or fatigue. Objective: Because COVID-19infection causes reduced blood flow which may cause [...]

Authors: Parhiz H, Brenner JS, Patel PN, Papp TE, Li Q, Shi R PMID: 34953981 PMCID: PMC8695324 DOI: 10.1016/j.jconrel.2021.12.027 Abstract Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has successfully paved the way for the highest clinical efficacy data from next-generation vaccinations against SARS-CoV-2 during the COVID-19 pandemic. However, such modmRNA-LNP technology has not been characterized [...]

Authors: Molina-Carballo A, Palacios-Lopez R, Jerez-Calero A, Agil A PMID: 35723382 PMCID: PMC8929125 DOI: 10.3390/cimb44010003 Abstract according to the World Health Organization (WHO), COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, responsible for an increasing number of cases and deaths. From a preventive and therapeutic point of view, there are two concerns that [...]

SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection. The novel variant of concern Omicron (B.1.1.529) has to date the largest number of amino acid alterations in its Spike protein. Thus, it may efficiently escape recognition by neutralizing antibodies, allowing breakthrough infections in convalescent and vaccinated individuals.

Authors: Kuyandik A, Ozcan E, Serin S, Sungurtekin H DOI: 10.4274/tybd.galenos.2021.91885 Abstract ABSTRACT Reports of neurological problems are increasing for the clinical presentation of COVID19. The clinical presentation reported in this study seemed to be a combination of nonspecific complications of the systemic disease, inflammation of the cerebrovascular system, and the effects of a direct [...]