Authors: Nicolson GL, Rosenblatt S, de Mattos GF, Settineri R, Breeding PC, Ash ME PMID: 32309576 PMCID: PMC6941554 DOI: 10.15190/d.2016.1 Abstract Membrane Lipid Replacement is the use of functional oral supplements containing cell membrane glycerolphospholipids and antioxidants to safely replace damaged membrane lipids that accumulate during aging and in various chronic and acute diseases. Most [...]

Auhtors: Scoccianti C, Key TJ, Anderson AS, Armaroli P, Berrino F, Cecchini M, et al. PMID: 26116994 DOI: 10.1016/j.canep.2014.12.007 Abstract Breast cancer is the most frequent cancer in women, and incidence rates have been rising in European Union (EU) countries over recent decades due in part to a sharp decline in breastfeeding practices. Evidence for [...]

Auhtors: Bradbury KE, Balkwill A, Spencer EA, Roddam AW, Reeves GK, Green J, et al. PMID: 24675385 PMCID: PMC4007233 DOI: 10.1038/bjc.2014.148 Abstract Background: Organically produced foods are less likely than conventionally produced foods to contain pesticide residues. Methods: We examined the hypothesis that eating organic food may reduce the risk of soft tissue sarcoma, breast [...]

Auhtors: Seyfried TN, Shelton LM PMID: 24343361 PMCID: PMC3941741 DOI: 10.1093/carcin/bgt480 Abstract Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular [...]

Authors: Nowotarski SL, Woster PM, Casero RA PMID: 23432971 PMCID: PMC4027058 DOI: 10.1017/erm.2013.3 Abstract Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport system. [...]

Auhtors: Seyfried TN Abstract The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was [...]

Auhtors: Seyfried TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P PMID: 20804725 DOI: 10.1016/j.bbabio.2010.08.009 Abstract Malignant brain tumors are a significant health problem in children and adults. Conventional therapeutic approaches have been largely unsuccessful in providing long-term management. As primarily a metabolic disease, malignant brain cancer can be managed through changes in [...]

Authors: Nicolson GL, Settineri R DOI: 10.31989/ffhd.v1i4.134 Abstract Background: Cancer-associated fatigue and the chronic adverse effects of cancer therapy can be reduced by Lipid Replacement Therapy (LRT) using membrane phospholipid mixtures given as food supplements. Methods: This is a review of the published literature on LRT and its uses. Results: LRT significantly reduced fatigue in [...]

Auhtors: Hanahan D, Weinberg RA PMID: 21376230 DOI: 10.1016/j.cell.2011.02.013 Abstract The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, [...]

Auhtors: Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, Vacchelli E, et al. PMID: 19698742 DOI: 10.1016/j.mam.2009.08.002 Abstract Mitochondria are required for cellular survival, yet can also orchestrate cell death. The peculiar biochemical properties of these organelles, which are intimately linked to their compartmentalized ultrastructure, provide an optimal microenvironment for multiple biosynthetic and [...]